Dubliner Seán was surrounded by traditional Irish music from an early age. Both parents were traditional fiddlers and he began playing the fiddle at a young age. He attended Dublin School of Music where he received classical training, but soon became one of Ireland's most talented young fiddlers, winning awards and such honours as the All-Ireland Championships and the Fiddler of Dooney competition, from which he earned the title of master fiddler.

A member of Ceoltóirí Cualann in the 1960's, Seán also performed with some of the trios and duets formed by Paddy Moloney in the 60's. It was 1968 before he joined The Chieftains on invitation from Paddy.

He has recorded a well received solo album, 'Seán Keane' and a duet album with fellow Chieftain Matt Molloy, 'Contentment is Wealth'. He has also recorded with Mick Moloney and his brother, James Keane on the album 'Reel Away the Real World' in 1980.
Sean lives in Dublin with his wife Marie, and they have 3 children and 4 grandchildren.